THERAPEUTIC TARGET DISCOVERY - UT MD ANDERSON CANCER CENTER
Genome-wide RNA interference (RNAi) libraries have been developed that provide a means to fundamentally change biological research by increasing the speed with which disease mechanisms and potential drug targets can be identified. RNA interference presents many opportunities for use in gene technology and double-stranded RNA molecules have been designed to activate the silencing of specific genes in humans, animals or plants. HTP of siRNA libraries have resulted in an explosion of vital information on the regulation of signaling pathways and drug targets. The opportunity to generate data by developing screens for novel targets for the treatment of diseases or unraveling biological processes has the potential to lead to the generation of new ideas. Thus the information generated from HTP RNAi screens is enormous contributing significantly to furthering our understanding of the complexities of biological systems.
